currently there are nine FDA approved medications to treat obesity additionally there are several medications that while not officially approved are frequently used off label for weight loss we're going to cover all these medications providing you with a comprehensive understanding of the various drugs currently being used for weight loss let's start with some weight loss medications approved for short-term use when we say shortterm it means that the Official Guidelines recommend using these drugs for no more than 3 months however this doesn't imply that their effectiveness abruptly stops at the 3 month Mark in reality many patients find these drugs beneficial for far longer the primary reason for the recommended duration is more about safety concerns since there isn't enough data from longer term studies we can't be certain if using these drugs for extended periods of time might lead to serious issues later on with that in mind let's start with fent turine it was one of the first short short-term weight loss medications approved by the FDA and is still in use today fenine works by stimulating the sympathetic nervous system leading to a significant decrease in appetite people taking phentramine can typically lose about 4.4% of their body weight compared to those taking a placebo this means that using fenine adds an additional 4.4% weight loss on top of any weight loss achieved through other dietary or lifestyle Chang changes like phentramine diprion also stimulates the sympathetic nervous system and is approved for short-term use in treating obesity it works by influencing the actions of norepinephrine patients using ditho proon can expect to lose approximately 6.6% of their body weight now let's move on to weight loss medications approved for long-term use which means utilizing these drugs for a year or more it's important to note that this doesn't guarantee continuous weight loss Beyond a year nor does it imply that they're more effective than short-term drugs the key difference is that studies have demonstrated the safety of using these medications for an extended period and have shown some weight loss when taken for a year or longer let's start with plenity it's the first medication approved for overweight adults whether or not they have other health issues unlike other drugs that are typically recommended for those with a higher BMI or have specific health conditions like diabetes plenti is a hydrogel matrix that absorbs water to expand and fill about 1/4 of the average stomach volume this promotes a feeling of fullness similar to how soluble fibers work for weight loss since it operates mechanically and not chemically plenity is considered a device rather than a drug making it safer for a broader range of overweight individuals however compared to other obesity medications plenity tends to be less effective showing only a modest 2% body weight loss orat AIDS weight loss by inhibiting lipases reducing the absorption of fat from the gastrointestinal tract the maximum recommended dose of orat can cut fat absorption by about 30% notably orat is available over the counter without a prescription in the United States under the brand name Aly a key consideration is that it works best when paired with a lowfat diet and not following this diet may lead to the medication's ineffectiveness or very messy side effects users of olat can anticipate an extra 3.8% body weight loss when combined with a lowfat diet contrave is a combination tablet containing buproprion and naltrexon buproprion is a reuptake inhibitor affecting dopamine and norepinephrine now trexon and opioid receptor antagonist enhances the effects of buproprion by reducing inhibitory feedback loops this combination results in reduced Cravings food intake and body weight contrave is particularly effective for patients dealing with emotional eating and food addiction however it does have significant effects on the brain leading to potential side effects like anxiety and mood changes nonetheless those who respond well to contrave can anticipate a 4.8% body weight loss when used in suitable patients seenda which is the drug lug glutide is also under the brand named Victor OA for diabetes this medication activates the glucagonlike peptide 1 or glp1 receptor which helps in reducing food intake curbing hunger and slowing digestion administered through a daily injection seenda has positive effects on blood sugar levels in diabetics as well as improvements in blood pressure and lipid levels users of Senda can anticipate a 5.4% body weight loss cmia is a controll release tablet that combines fenine and Topiramate fenine stimulates the sympathetic nervous system decreasing food intake and potentially increasing energy expenditure to Pyramid approved for epilepsy and migraine prophylaxis AIDS in weight loss through promoting taste adversion by making food taste Bland and reducing food intake that way cmia combines the two and effectively reduces appetite and binge eating it is considered safer for long-term use compared to fenine alone while being just as if not more effective for weight loss users of cemia can expect an 88.6% body weight loss wavi which is the drug semaglutide is also under the brand name OIC for diabetes similar to Senda but considered stronger and longer lasting semaglutide is administered through weekly injections it works by suppressing food intake reducing hunger and slowing digestion wovi marked a new generation of weight loss medication that were highly effective while being somewhat safer to take for example rather than potentially causing cardiovascular problems individuals on wavi have shown cardiovascular benefits patients using wavi can anticipate a 12.4% body weight loss Zep bound which is the drug tepati is also under the brand name monjaro for diabetes this dual receptor activator targets both glp1 and another receptor called GI P resulting in a more potent suppression of food intake reduced hunger and slow digestion with potentially fewer side effects administered through weekly injections Zep bound is currently one of the most effective weight loss medications to date although this may change soon with the introduction of rutti users can expect a 15.4% body weight loss now let's discuss some medications that are commonly used off label for weight loss when we say off lab it means that Healthcare Providers prescribe a medication not specifically approved by the FDA as a weight loss drug these medications might have originally been developed and approved for other purposes but their side effects or other actions May hint at potential benefits for weight management clinicians often consider these medications on a caseby casee basis to support weight loss however due to their off Lael use there's typically less research investigating their effectiveness or safety for weight loss the evidence may be less clear-cut or more challenging to interpret making it harder to determine their true Effectiveness compared to approved medications additionally off Lael medications are generally less potent for weight loss and may be trickier to use correctly they might also lead to more severe side effects and may not be as safe for long-term use therefore seeking guidance from a doctor is a must starting with buproprion initially designed for depression and smoking sensation it has a side effect of causing weight loss while the weight loss observed with buproprion is modest it stands out as a preferred alternative to many anti-depressants that often lead to weight gain when used off label for weight loss buproprion is typically administered in sustained release formulations at doses of 400 mg and results in an average weight loss of around 2.8% body weight metformin is an anti-diabetic drug that lowers glucose production uction and enhances insulin sensitivity this not only reduces blood sugar levels but also contributes to a small amount of weight loss studies on patients with diabetes consistently show approximately 2 to 3% weight loss Beyond a placebo with more significant weight loss and those with higher insulin resistance pramlintide is an injection approved for diabetes treatment pramin tide mimics the action of the hormone amalin which helps to regulate blood sugar levels its impact on weight loss is believed to be mediated through brain receptors that improve appetite control treatment with pramlintide resulted in a placeable corrected reduction in body weight of about 3.7% sodium glucose Transporter 2 or sglt2 Inhibitors is yet another class of medications primarily used for diabetes these drugs promote glucose removal through urine leading to lower blood sugar levels four sglt2 Inhibitors are approved in the US anaglyph loin dag glyphen erug glyphen and empa glyphen they have shown around a 2 to 3% body weight loss in studies involving adults with type 2 diabetes toymate is originally an anti-epileptic drug also approved for migraine prevention it is found to reduce body weight in various disorders randomized control trials demonstrate that to pyramid is both tolerable and effective resulting in patients losing around 2 to 3% of their body weight lastly zon another anti-epileptic medication has shown in randomized control studies to promote modest weight loss ranging from 2 to just over 3% body weight loss in patients with obesity the weight loss drugs available today are just a glimpse of what's on the horizon the past few years have brought more advancements to the drug weight loss industry than we've seen in decades if you're curious about upcoming and new weight loss medications take a look at my detailed review in the description [Music] below hi I'm Dr Brian Young what are some of your experiences using these weight loss medications let me know in the comments down below subscribe and hit the notification B to stay up to date and you found this video informative please leave me a like and share this video 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